Researchers from SUNY University at Buffalo (UB) have discovered the role the Slc4a11 protein plays in congenital hereditary endothelial dystrophy (CHED).
According to researchers, Slc4a11 is a transport protein found in endothelial cells in the cornea, inner ear and kidneys that reportedly moves the equivalent of pure acid, making it only the second such protein identified in mammals to do so. In the cornea, the scientists believe Slc4a11 acts as manager working to keep its pH balance correct so as not to experience any issues. In this manner, the protein helps support corneal physiology and health, and mutations would affect the cells in the cornea.
The study was recently published online in the American Journal of Physiology — Cell Physiology.
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Source: SUNY University at Buffalo