Allegro Ophthalmics, LLC has announced earlier this week the company’s expansion of its anti-integrin portfolio with the new front-of-the-eye-drug candidate ALG-1007. ALG-1007 is a topical treatment in development for potential use in patients with dry eye disease (DED), a condition affecting millions of people in the United States.
ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate®), currently being developed for diabetic macular edema (DME) and intermediate dry age-related macular degeneration (intermediate dry AMD). Pre-clinical and clinical findings of risuteganib convinced the company that it could develop a new anti-integrin compound to treat DED.
“While there are a number of good therapies for dry eye disease, this is a multifactorial disease and there remain unmet needs. I am enthusiastic about the early ex-U.S. proof-of- concept data that I’ve seen and look forward to working with my colleagues Drs. Donnenfeld and Holland, who share my enthusiasm, in helping Allegro drive the next phase of this drug candidate forward,” said Richard L. Lindstrom, M.D. Dr. Lindstrom will serve as Chairperson of the company’s newly formed Cornea Scientific Advisory Board (Cornea SAB) to provide strategy and direction on Allegro’s clinical development pipeline in the areas of corneal disease and dry eye.
“While we remain focused on and committed to our retina portfolio, we at Allegro are continuously exploring new ways to apply our anti-integrin assets to help improve patients’ vision,” said Vicken Karageozian, M.D., President and CEO of Allegro Ophthalmics. “ALG-1007 represents Allegro’s first exploratory drug beyond the retina. We recognize the need to bring in independent external expertise that complements our company’s strengths and are thrilled to have such an outstanding group of advisors as Drs. Lindstrom, Holland and Donnenfeld help shape and accelerate our clinical program for dry eye disease.”
News Source:
https://www.allegroeye.com/allegro-ophthalmics-expands-its-anti-integrin-portfolio-with-new-front-of-the-eye-drug-candidate-alg-1007-for-the-treatment-of-dry-eye-disease/
Source: Allegro Ophthalmics