A study from a research team in Taiwan have shown that people with type 2 diabetes who took metformin, a common diabetes medication, had a significantly lower rate of age-related macular degeneration (AMD). The study suggests that the anti-inflammatory and anti-oxidative effects of metformin can protect against AMD in addition to controlling diabetes.
Inflammation and oxidative stress have long been known to play a key role in the development of both diabetes and AMD. Because metformin suppresses inflammation and oxidative stress, researchers in Taiwan theorized that perhaps the diabetes drug may also protect against AMD, one of the leading causes of blindness in Americans over age 50, affecting about 2.1 million people nationwide.
Using the Taiwan National Health Insurance Research Database, the team collected data on all patients recently diagnosed with type 2 diabetes from January 2001 to December 2013, dividing them into two groups: Those who took metformin (45,524 patients) and those who did not (22,681 patients). After following both groups for 13 years, the researchers found that patients in the metformin group had a significantly lower risk of developing AMD. Half as many patients in the metformin group had AMD compared to the control group.
“Our study is the first to reveal the protective effect of metformin on the development of AMD,” said lead investigator, Yu-Yen Chen, M.D. “While more study is required to determine just how metformin protects against the development of AMD, this is an exciting development for patients at risk.” The study findings were presented on October 28 at AAO 2018, the 122nd Annual Meeting of the American Academy of Ophthalmology.
Read the full news release from AAO.
Source: American Academy of Ophthalmology