Scientists from The Scripps Research Institute (TSRI) have recently discovered how a protein called α2δ4 establishes proper vision, and their research also helps explain why mutations in the gene encoding this protein can lead to retinal dystrophy.
Using a mouse model, researchers reportedly found α2δ4 plays an important role in ensuring rods can connect to the neural circuit. Additionally, they found a lack of α2δ4 also impacted cones where mice could not see under dim light conditions.
Next, the researchers reportedly plan to study whether α2δ4 could help photoreceptors transmit their signals and maintain connectivity to stay functional longer in models of age-related vision loss.
The study was recently published in the journal Neuron.
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Source: The Scripps Research Institute