Wayne State University has received a five-year, $1.925 million grant from the National Eye Institute (NEI) to test the role of microRNAs (miRNAs) in bacterial keratitis, as well as to identify new therapeutic targets and alternative treatment strategies.
The research team — led by Dr. Shunbin Xu, associate professor of ophthalmology and anatomy and cell biology in the School of Medicine at Wayne State — reportedly plans to test the role of the miR-183/96/182 cluster and the mechanisms by which it regulates the innate immune response to Pseudomonas aeruginosa (PA)-induced keratitis, as well as the potential of knockdown of the cluster function by anti-miRs to protect the cornea from adverse effects of the disease.
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Source: Wayne State University