A team of researchers from the University of California San Diego School of Medicine, with colleagues at Case Western University, Duke University, and the National Institutes of Health (NIH) have identified three novel genomic loci — distinct stretches of genetic material on chromosomes — linked to Fuchs endothelial corneal dystrophy (FECD), helping to deepen understanding of the pathology and, in turn, develop better therapies for treating and preventing the disease.
According to researchers, previously there was one known FECD locus, and this new finding expands that number to four. The team reportedly conducted a genome-wide association study, which confirmed the known role of the TCF4 gene, but also revealed associations with three other loci — KANK4, LAMC1 and LINC009970/ATPB1. Researchers also found some genomic markers that were more associated by gender, with LAMC1 increasing FECD risk in women while TCF4 increased risk in men.
The study was recently published in the journal Nature Communications.
Click here to read the full press release.
Like what you read? Follow OphthalmologyWeb to keep up with our latest articles, news and events. Plus, get special offers and more delivered to your inbox.
Source: UC San Diego Health