Noted cataract surgeon, Dr. Stephen Lane discusses intracameral antibiotic use in cataract patients for the prophylaxis of endophthalmitis in a conversation with Dr. David Goldman. Dr. Lane reviews recent European data on cefuroxime in detail. Fourth generation fluoroquinolones are very popular in the US and used in most cases. Vigamox (moxifloxacin), preservative free, has the potential to be used intracamerally. Two recent studies (Dr. Steve Arshinoff, Canada, and Dr. Cesar Espiritu, Philippines) show no adverse effects. This was the groundwork for a US study undertaken with Drs. Stephen Lane, Sam Maskett, and Robert Osher. 0.01cc Vigamox used in 60 patients vs. BSS. Safety shown, efficacy will need a more powered study(>20k pts). Dr. Lane then describes the use of intracameral antibiotics in his own cataract practice.