The glaucoma medications associated with decreased conjunctival goblet cell density are:

  1. Prostaglandin analogs
  2. Selective beta blockers
  3. Non-selective beta blockers
  4. Alpha agonists

Correct Answer: Non-selective beta blockers

Non-cardio selective beta-blockers, such as timolol and levobunolol, have been associated with decreased conjunctival goblet cell density. Corneal sensitivity may be decreased with these agents. Topical beta blockers with intrinsic sympathomimetic agents, such as carteolol, have fewer systemic side effects, less effect on corneal sensitivity, decreased stinging and red eye and better local tolerability.

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