Ophthalmology
Jean-Claude Mwanza, Mary K. Durbin, Donald L. Budenz, Fouad E. Sayyad Robert T. Chang, Arvind Neelakantan, David G. Godfrey, Randy Carter, Alan S. Crandall
119(6): 1151-1158 June 2012
Purpose
To determine the diagnostic performance of macular ganglion cell–inner plexiform layer (GCIPL) thickness measured with the Cirrus high-definition optical coherence tomography (HD-OCT) ganglion cell analysis (GCA) algorithm (Carl Zeiss Meditec, Dublin, CA) to discriminate normal eyes and eyes with early glaucoma and to compare it with that of peripapillary retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) measurements.
Design
Evaluation of diagnostic test or technology.
Participants
Fifty-eight patients with early glaucoma and 99 age-matched normal subjects.
Methods
Macular GCIPL and peripapillary RNFL thicknesses and ONH parameters were measured in each participant, and their diagnostic abilities were compared.
Main Outcome Measures
Area under the curve (AUC) of the receiver operating characteristic.
Results
The GCIPL parameters with the best AUCs were the minimum (0.959), inferotemporal (0.956), average (0.935), superotemporal (0.919), and inferior sector (0.918). There were no significant differences between these AUCs and those of inferior quadrant (0.939), average (0.936), and superior quadrant RNFL (0.933); vertical cup-to-disc diameter ratio (0.962); cup-to-disc area ratio (0.933); and rim area (0.910), all P>0.05.
Conclusions
The ability of macular GCIPL parameters to discriminate normal eyes and eyes with early glaucoma is high and comparable to that of the best peripapillary RNFL and ONH parameters.