Dr. Ashok Kumar, assistant professor of ophthalmology, anatomy and cell biology, microbiology, immunology, and biochemistry in the School of Medicine and Kresge Eye Institute at Wayne State University, has received a $1.9 million grant from the National Eye Institute of the National Institutes of Health to study bacterial endophthalmitis.
Through his project, "Role of AMP-Activated Protein Kinase in Bacterial Endophthalmitis," Kumar will reportedly use a mouse model of bacterial endophthalmitis and cultured monocytes/macrophages to study the role of a metabolic gene AMP-activated protein kinase (AMPK) in regulating innate responses in endophthalmitis.
Kumar and his research team will reportedly look at the link between AMP-activated protein kinase-regulated energy metabolism of monocytes and macrophages, and their role in regulating innate responses in bacterial endophthalmitis. They reportedly hope to identify novel pathways and new means to treat blinding ocular infections.
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Source: Wayne State University